Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery
Acute Pain · Opioid Analgesic Adverse Reaction
Enrolment: 606 · Results not recorded
Loading the evidence…
Drug · AGONIST of mu opioid receptor (CHEMBL233)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Pain · Opioid Analgesic Adverse Reaction
Enrolment: 606 · Results not recorded
Gynecologic Surgical Procedures · PONV · Laparoscopy
Enrolment: 96 · Results not recorded
Cough · Anesthesia
Enrolment: 62 · Results not recorded
Acute Pain
Enrolment: 418 · Results not recorded
Pain, Acute
Enrolment: 30 · Results not recorded
Vitrectomy
Enrolment: 120 · Results not recorded
Rebound Pain · Arthroscopic Knee Surgery
Enrolment: 320 · Results not recorded
Postoperative Analgesia
Enrolment: 80 · Results not recorded
Gynecological Laparoscopic Surgery · General Anesthetic · Intubation
Enrolment: 120 · Results not recorded
Postoperative analgesia
Enrolment: 90 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Right tibial fracture with intramedullary pinning using a 27-gauge stainless steel needle, with sham-operated controls; plus tail flick and von Frey assays in uninjured mice
Oliceridine was about four times more potent than morphine in the tail flick assay (ED50 1.31 mg/kg versus 5.26 mg/kg) and produced no analgesic tolerance, less opioid-induced hyperalgesia, better recovery of nociceptive sensitisation and gait after tibial fracture, and no rise in spinal TLR4 mRNA.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.