Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin.
MouseOtherC57BL/6Male and femaleClonidine intrathecal; route for metformin and gabapentin not statedMetformin 200 mg/kg; gabapentin 100 mg/kg; clonidine a sing…
Model: Spared nerve injury model of neuropathic pain
Metformin completely reversed the pain-related set-shifting deficit and restored axon initial segment length in the infralimbic cortex, gabapentin worsened the impairment in both injured and sham mice, and clonidine had no effect on set-shifting.
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