Effect of Da-Cheng-Qi decoction for treatment of acute kidney injury in rats with severe acute pancreatitis.
RatChemical/toxinSprague-Dawleymalen = 40 rats across 5 groupsIntragastric6 g/kg body weight (low), 12 g/kg (medium) and 24 g/kg (hig…2 hours after induction of severe acute pancreatitis
Model: Severe acute pancreatitis induced by retrograde biliopancreatic duct infusion of 3.5 per cent sodium taurocholate at 0.2 mL/min (1 mL/kg), with secondary acute kidney injury
All doses lowered kidney IL-6 and TNF-alpha and raised IL-4 and IL-10 relative to the model group, with the high dose giving the largest effect and the lowest pancreatic and renal pathological scores. Serum creatinine fell significantly in the high dose group, while blood urea nitrogen did not diff…
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