Dexmedetomidine Protects Against Traumatic Brain Injury-Induced Acute Lung Injury in Mice.
MouseTBIControlled cortical impactC57BL/6malen = n=8 per group across 5 groupsIntraperitoneal injection50 microgram/kg in 200 microlitre; atipamezole comparator 2…Immediately after traumatic brain injury; atipamezole given 15 minutes before
Model: Feeney weight-drop controlled cortical impact after 3 mm craniotomy over the left parietal cortex, with secondary acute lung injury
Dexmedetomidine reduced lung injury score, bronchoalveolar lavage protein concentration and lung wet-to-dry ratio at 24 hours, and lowered serum HMGB1 and lung RAGE expression. The alpha-2 antagonist atipamezole partly reversed these effects, indicating dependence on alpha-2 adrenoceptor agonism.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.