Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels.
RatWoundSprague-DawleyMalen = 16 male Sprague-Dawley rats, four groups of four animals, t…Topical application to the wound bed0.5 g of poly(vinyl alcohol)-borate hydrogel applied per wo…Treatment started on the day of wounding (day 0)
Model: Two circular full-thickness excisional wounds of 6.0 mm diameter created with a punch biopsy tool on the dorsal thoracic area, in streptozotocin-induced diabetic and non-diabetic rats; wounds splinted with silicone and covered with an occlusive dressing
In non-diabetic rats free insulin gave no significant benefit over control while insulin-loaded nanoparticles did (p < 0.001); in diabetic rats both forms improved healing, with the nanoparticle formulation better, the difference in percentage wound injury index against control at day 10 being 29.1…
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