THERAPY DOSSIER · th-7b383bea317e

Recombinant human insulin loaded in poly(lactide-co-glycolide) nanoparticles embedded in a poly(vinyl alcohol)-borate hydrogel

Biologic · Recombinant human insulin in PLGA nanoparticles/PVA-borate hydrogel (topical, for wound healing); insulin is clinically tested topically for wounds.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Recombinant human insulin in PLGA nanoparticles/PVA-borate hydrogel (topical, for wound healing); insulin is clinically tested topically for wounds.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04390815 ↗Injury indicationPHASE4unknown

Effect of Insulin on Wound Healing - A Randomized Controlled Trial

Wound Heal

Enrolment: 30 · Results not recorded

NCT06708975 ↗NAnot yet recruiting

Effect of Transdermal Insulin Therapy on Wound Healing of Chronic Diabetic Patients

Diabetes Mellitus

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29971752 ↗2018Reported benefit

Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels.

RatWoundSprague-DawleyMalen = 16 male Sprague-Dawley rats, four groups of four animals, t…Topical application to the wound bed0.5 g of poly(vinyl alcohol)-borate hydrogel applied per wo…Treatment started on the day of wounding (day 0)

Model: Two circular full-thickness excisional wounds of 6.0 mm diameter created with a punch biopsy tool on the dorsal thoracic area, in streptozotocin-induced diabetic and non-diabetic rats; wounds splinted with silicone and covered with an occlusive dressing

In non-diabetic rats free insulin gave no significant benefit over control while insulin-loaded nanoparticles did (p < 0.001); in diabetic rats both forms improved healing, with the nanoparticle formulation better, the difference in percentage wound injury index against control at day 10 being 29.1…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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