Beta-Hydroxy-Beta-Methyl-Butyrate, L-glutamine, and L-arginine Supplementation Improves Radiation-Induce Acute Intestinal Toxicity.
RatRadiationWistarFemalen = 40 rats in four groupsStarted on the day of radiotherapy
Model: Radiation-induced acute intestinal toxicity (abdominal radiotherapy)
Compared with radiotherapy alone, combined supplementation significantly reduced surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis, and vascular dilatation and congestion. TGF-beta staining scores did not differ between the radiotherapy-only and supplemented grou…
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