Oral Nutritional Supplement With beta-hydroxy-beta-methylbutyrate on Thigh Muscle Mass in Pre-frail Older People
Frail Elderly Syndrome · Nutrition Disorders in Old Age · Muscle Loss
Enrolment: 70 · Results not recorded
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Nutraceutical · Three-component nutraceutical formulation (HMB, L-glutamine, L-arginine; marketed as Juven). No single ChEMBL entity exists for the combination, so resolved=false and ChEMBL fields are left empty. For reference only, the HMB component alone corresponds to ChEMBL CHEMBL4303793 (beta-hydroxyisovaleric acid, max_phase 3, synonym Juven), which has no ChEMBL mechanism-table record. Proposed action is anti-catabolic support of muscle protein balance and wound healing; not a ChEMBL-curated mechanism.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Frail Elderly Syndrome · Nutrition Disorders in Old Age · Muscle Loss
Enrolment: 70 · Results not recorded
Sarcopenia
Enrolment: 32 · Results not recorded
Impaired Glucose Tolerance
Enrolment: 36 · Results not recorded
Frailty · Muscle Weakness · Multiple Chronic Conditions
Enrolment: 25 · Results not recorded
Muscle Damage · Body Weight Changes
Enrolment: 69 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Radiation-induced acute intestinal toxicity (abdominal radiotherapy)
Compared with radiotherapy alone, combined supplementation significantly reduced surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis, and vascular dilatation and congestion. TGF-beta staining scores did not differ between the radiotherapy-only and supplemented grou…
Extraction: extract · Supplied extraction confidence: 0.66. Machine-extracted fields require source verification.
Model: Single 17 Gy radiation dose to the head and neck area causing acute oral mucositis
HMB/Glu/Arg reversed radiation-induced epithelial atrophy (p 0.006) and significantly reduced radiation-induced inflammation (p 0.007).
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.