Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats.
RatWoundFischer 344Malen = 46 male rats in total: 11 incision plus morphine and 10 inc…Subcutaneous1 mg/kgGiven after incision, 30 minutes before each daily behavioural session
Model: Hindpaw plantar surgical incision under isoflurane anaesthesia
Incision impaired attentional performance, raising area under the median cue duration-time curve to 97.2 (SD 56.8) s-days versus 25.5 (SD 14.5) s-days for anaesthesia control. Morphine 1 mg/kg reduced this impairment to 31.6 (SD 36.7) s-days versus 110.0 (SD 64.7) s-days with saline, and the morphi…
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