Youthful systemic milieu alleviates renal ischemia-reperfusion injury in elderly mice.
MouseIschaemia-reperfusionRenalC57BL/6MaleSurgical parabiosis (shared circulation)Parabiosis established three weeks before induction of renal ischaemia-reperfus…
Model: Bilateral renal ischaemia-reperfusion injury
Old mice joined to young partners showed less renal histological injury and better renal function than old-old parabiotic pairs, with significantly reduced renal oxidative stress, inflammation and apoptosis and significantly increased autophagy. Old-old parabiosis alone improved renal function but…
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