THERAPY DOSSIER · th-09411826a2c2

Parabiosis with a young mouse (youthful systemic milieu)

Procedure · Parabiosis with a young mouse (youthful systemic milieu); experimental physiological procedure.

Evidence & regulatory context

Mechanism: Parabiosis with a young mouse (youthful systemic milieu); experimental physiological procedure.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29935950 ↗2018Reported benefit

Youthful systemic milieu alleviates renal ischemia-reperfusion injury in elderly mice.

MouseIschaemia-reperfusionRenalC57BL/6MaleSurgical parabiosis (shared circulation)Parabiosis established three weeks before induction of renal ischaemia-reperfus…

Model: Bilateral renal ischaemia-reperfusion injury

Old mice joined to young partners showed less renal histological injury and better renal function than old-old parabiotic pairs, with significantly reduced renal oxidative stress, inflammation and apoptosis and significantly increased autophagy. Old-old parabiosis alone improved renal function but…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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