Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury.
MouseSpinal cord injuryContusionC57BL/6Femalen = 40 mice randomised into four groups (10 per group)Subdural injectionSingle dose of 1 x 10 TU (exponent not recoverable from the…Immediately following spinal cord contusion
Model: Acute thoracic spinal cord contusion
miR-21 knockdown improved Basso Mouse Scale scores at day 14 after surgery compared with untreated injury (p < 0.01), produced the clearest histological recovery with axonal regeneration and restored neuronal morphology, significantly reduced serum TGF-beta1, TNF-alpha and IL-1beta, upregulated BDN…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.