THERAPY DOSSIER · th-51fdcdcc43b3

MicroRNA-21 knockdown vector

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29934690 ↗2018Reported benefit

Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury.

MouseSpinal cord injuryContusionC57BL/6Femalen = 40 mice randomised into four groups (10 per group)Subdural injectionSingle dose of 1 x 10 TU (exponent not recoverable from the…Immediately following spinal cord contusion

Model: Acute thoracic spinal cord contusion

miR-21 knockdown improved Basso Mouse Scale scores at day 14 after surgery compared with untreated injury (p < 0.01), produced the clearest histological recovery with axonal regeneration and restored neuronal morphology, significantly reduced serum TGF-beta1, TNF-alpha and IL-1beta, upregulated BDN…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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