Short time insulin treatment post burn improves elastic-collagen rearrangement and reepithelization.
RatBurnScaldWistarMale5 UI/kg/dayAfter scald burn injury
Model: Scald burn injury covering 45 per cent of total body surface area
Insulin for four days increased the volume fraction of thin collagen and of elastic fibres and stimulated re-epithelialisation in burned rats, with a new muscle layer visible at 14 days. Untreated burned animals had a higher volume fraction of thick collagen at four days whereas insulin-treated ani…
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