Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats.
RatOtherSprague-DawleyMale and femaleIntrathecalAfter nerve injury, once allodynia was established
Model: Peripheral nerve injury producing mechanical allodynia
Nerve injury caused comparable allodynia and reactive microgliosis in both sexes, but spinal microglial inhibition and intrathecal P2X4 receptor blockade reversed allodynia only in male rats. Nerve injury increased P2X4 receptor surface expression and function in spinal microglia from male but not…
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