THERAPY DOSSIER · th-81bc5f4695db

P2X4 receptor antagonist administered intrathecally; also intrathecal microglial inhibition and transfer of P2X4R-stimulated microglia

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29927790 ↗2018Mixed findings

Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats.

RatOtherSprague-DawleyMale and femaleIntrathecalAfter nerve injury, once allodynia was established

Model: Peripheral nerve injury producing mechanical allodynia

Nerve injury caused comparable allodynia and reactive microgliosis in both sexes, but spinal microglial inhibition and intrathecal P2X4 receptor blockade reversed allodynia only in male rats. Nerve injury increased P2X4 receptor surface expression and function in spinal microglia from male but not…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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