Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.
MouseOtherC57BL/6JFemalen = 62 C57BL/6J female mice in total (54 tendon injury, 8 sham)…Intraperitoneal100 mg/kg (100 microlitres per mouse)From 1 day after tendon transection surgery
Model: Complete transverse incision (surgical rupture) at the midpoint of the right Achilles tendon, gap left open
DCA reduced carbon-labelled lactate generation at 1 and 4 weeks, decreased tendon cross-sectional area and increased modulus, maximum stress and maximum force relative to vehicle at 4 weeks. Collagen fibre alignment improved and mucoid (glycosaminoglycan) accumulation and ectopic calcification were…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.