THERAPY DOSSIER · th-b6b9faf2a104

Dichloroacetate (sodium dichloroacetate, DCA)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL13960 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Dichloroacetate; Dichloroacetic acid; Dichloroethanoic acid; Bichloroacetic acid; Bichloracetic acid; Dichloracetic acid; Dichlorethanoic acid; Sodium dichloroacetate; DCA; NSC-2654
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02616484 ↗PHASE3active not recruiting

Phase 3 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency

Pyruvate Dehydrogenase Complex Deficiency

Enrolment: 34 · Results not recorded

NCT01029925 ↗PHASE2terminated

Dichloroacetate in Previously Treated Metastatic Breast or NSCLC

Metastatic Breast Cancer · Lung Cancer

Enrolment: 7 · Results not recorded

NCT00004493 ↗PHASE2completed

Sodium Dichloroacetate in Congenital Lactic Acidemia

Lactic Acidosis

Enrolment: 75 · Results not recorded

NCT03356457 ↗EARLY_PHASE1completed

Agents to Diminish Hypoglycemia-induced Brain Injury in Type 1 Diabetes

Hyperglycaemia (Diabetic)

Enrolment: 21 · Results not recorded

NCT01083524 ↗PHASE1completed

Dichloroacetate in Advanced Pulmonary Arterial Hypertension

Pulmonary Hypertension

Enrolment: 30 · Results not recorded

NCT00874276 ↗NAcompleted

Pharmacotoxicology of Trichloroethylene Metabolites (Congenital Lactic Acidosis)

Congenital Lactic Acidosis

Enrolment: 21 · Results not recorded

NCT00015015 ↗NAcompleted

Dichloroacetate Kinetics, Metabolism and Toxicology

Lactic Acidosis

Enrolment: 100 · Results not recorded

NCT06931262 ↗NAavailable

Expanded Access with Dichloroacetate Sodium for PDC Deficiency

Pyruvate Dehydrogenase Complex Deficiency

Enrolment not recorded · Results not recorded

NCT04046081 ↗NAcompleted

Dichloroacetate for Endometriosis-associated Pain

Endometriosis

Enrolment: 30 · Results not recorded

NCT00031161 ↗NAcompleted

Prevention of Dichloroacetate Toxicity

Acidosis, Lactic · Chronic Disease

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29927623 ↗2018Reported benefit

Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.

MouseOtherC57BL/6JFemalen = 62 C57BL/6J female mice in total (54 tendon injury, 8 sham)…Intraperitoneal100 mg/kg (100 microlitres per mouse)From 1 day after tendon transection surgery

Model: Complete transverse incision (surgical rupture) at the midpoint of the right Achilles tendon, gap left open

DCA reduced carbon-labelled lactate generation at 1 and 4 weeks, decreased tendon cross-sectional area and increased modulus, maximum stress and maximum force relative to vehicle at 4 weeks. Collagen fibre alignment improved and mucoid (glycosaminoglycan) accumulation and ectopic calcification were…

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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