Anti-inflammatory and anti-fibrotic treatment in a rodent model of acute lung injury induced by sulfur dioxide.
RatChemical/toxinSprague-DawleyFemalePirfenidone 200 mg/kg; dexamethasone 10 mg/kg1, 5 and 23 h after sulfur dioxide exposure
Model: Sulfur dioxide inhalation (2200 ppm, nose-only exposure, 10 min) causing acute lung injury with airway hyperresponsiveness and later fibrosis
Both pirfenidone and dexamethasone significantly reduced the total leukocyte response in bronchoalveolar lavage fluid and suppressed pulmonary oedema. Pirfenidone, unlike dexamethasone, reduced methacholine-induced airway hyperresponsiveness to almost control levels and partially suppressed acute m…
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