Drug · ChEMBL curates the mechanism of action as 'Unknown' (FDA label reference); antifibrotic agent, ATC L04AX05, direct_interaction true, disease_efficacy true.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Lung Injury · Prevention
Enrolment: 214 · Results not recorded
Connective Tissue Diseases · Interstitial Lung Disease
Enrolment: 120 · Results not recorded
Systemic Sclerosis-associated ILD
Enrolment: 144 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 344 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 555 · Results not recorded
Idiopathic Pulmonary Fibrosis (IPF)
Enrolment: 472 · Results not recorded
Chronic Kidney Disease
Enrolment: 200 · Results not recorded
Pulmonary Fibrosis · Oculocutaneous Albinism
Enrolment: 35 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 20 · Results not recorded
Rheumatoid Arthritis Interstitial Lung Disease
Enrolment: 123 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 80 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 160 · Results not recorded
Uterine Leiomyoma · Fibroids
Enrolment: 32 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 21 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 24 · Results not recorded
Asbestosis
Enrolment: 40 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Caustic oesophageal burn produced by application of 32% sodium hydroxide to the distal oesophagus
Pirfenidone reduced endoscopic and radiographic stenosis and collagen deposition and lowered profibrogenic gene expression, with MMP-2 unchanged.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Sulfur dioxide inhalation (2200 ppm, nose-only exposure, 10 min) causing acute lung injury with airway hyperresponsiveness and later fibrosis
Both pirfenidone and dexamethasone significantly reduced the total leukocyte response in bronchoalveolar lavage fluid and suppressed pulmonary oedema. Pirfenidone, unlike dexamethasone, reduced methacholine-induced airway hyperresponsiveness to almost control levels and partially suppressed acute m…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Kainic acid-induced excitotoxic hippocampal injury with limbic seizures, induced by intraperitoneal injection of 12 mg/kg kainic acid
Pirfenidone dramatically reduced microglial activation seen with isolectin B4 staining and MHC II immunohistochemistry, and down-regulated inducible nitric oxide synthase mRNA measured 6 h after kainic acid injection.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
