Emodin Attenuates Autophagy Response to Protect the Pancreas From Acute Pancreatitis Failure.
RatChemical/toxinWistarMaleIntragastric40 mg/kg per day2 h after induction of acute pancreatitis
Model: Acute pancreatitis induced by injection of 3% sodium taurocholate into the biliopancreatic duct
Emodin-treated rats showed significantly alleviated pancreatic pathological injury and reduced autophagic vacuole formation in acinar cells, with reduced protein levels of LC3 (B/A) and p62 but not beclin-1, and reduced transcript levels of LC3B, beclin-1 and p62.
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