Randomized Clinical Trial of Triptolide Woldifii for Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Polycystic Kidney
Enrolment: 300 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Polycystic Kidney
Enrolment: 300 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute pancreatitis induced by injection of 3% sodium taurocholate into the biliopancreatic duct
Emodin-treated rats showed significantly alleviated pancreatic pathological injury and reduced autophagic vacuole formation in acinar cells, with reduced protein levels of LC3 (B/A) and p62 but not beclin-1, and reduced transcript levels of LC3B, beclin-1 and p62.
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Model: Severe acute pancreatitis with associated acute lung injury induced by retrograde injection of 5 per cent sodium taurocholate at 1 ml/kg into the biliary-pancreatic duct under chloral hydrate anaesthesia
Emodin, like FK866 and dexamethasone, significantly downregulated pre-B-cell colony-enhancing factor in peripheral blood neutrophils, reduced serum amylase activity and lung and pancreas wet to dry weight ratios, alleviated lung and pancreatic histological injury and promoted neutrophil apoptosis t…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by injecting sodium taurocholate into the pancreatic and biliary duct
Emodin ameliorated pancreatic injury, lowered amylase and inflammatory cytokines and significantly reduced Bip, IRE1 alpha, TRAF2 and ASK1 expression and JNK and p38 MAPK phosphorylation at all time points.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.