FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone.
RatSpinal cord injuryCompressionWistarMalen = 35 adult male rats randomly allocated to five groupsAfter induction of spinal cord injury
Model: Clip compression of the spinal cord at a determined level
Spinal cord injury reduced Purkinje cell numbers and increased FNDC5 expression. Methylprednisolone inhibited apoptosis in FNDC5-immunoreactive Purkinje cells, restored these cells and reduced FNDC5 expression relative to untreated injury.
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