Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17beta-estradiol in female tumor-bearing spontaneously hypertensive rats.
RatChemical/toxinSpontaneously hypertensive rat (SHR) and ovariectomised SHR, bearing SST-2 mammary tumoursFemalen = 20 per estrous stage in the estrous-staged experiment; 6 to…Subcutaneous time-release pelletHormone pellets implanted before the single doxorubicin injection
Model: Doxorubicin-induced cardiotoxicity, single doxorubicin 10 mg/kg by lateral tail vein injection 24 h after subcutaneous implantation of 8.5 x 10^6 SST-2 cells into the right mammary fat pad
Exogenous 17beta-estradiol suppressed doxorubicin-induced cardiotoxicity in ovariectomised SHRs, while progesterone-implanted animals were only partly resistant and the estradiol plus progesterone combination gave no cardioprotection. Estrous stage at treatment altered damage, with proestrus-treate…
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