Abrupt Deflation after Sustained Inflation Causes Lung Injury.
RatOtherSprague-DawleyMalen = 6 per group for the main ventilation comparison, 4 per grou…Given in association with the deflation manoeuvre
Model: Ventilator-induced lung injury caused by abrupt deflation to zero positive end-expiratory pressure after sustained inflation (positive end-expiratory pressure raised from 3 to 11 cm H2O over 70 min), with low tidal volume ventilation at 6 ml/kg
Abrupt deflation reduced compliance (0.48 +/- 1.0 vs 0.82 +/- 0.2) and oxygen saturation (67 +/- 23.5% vs 91 +/- 4.4%) and increased wet to dry ratio (6.1 +/- 0.6 vs 4.6 +/- 0.4) with predominantly endothelial injury. Sodium nitroprusside prevented the rise in systemic blood pressure and left ventr…
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