THERAPY DOSSIER · th-6536c43654cf

Sodium nitroprusside

Drug · ACTIVATOR of soluble guanylate cyclase (heterodimer; beta 1 or 2 subunit is the binding site). Nitric oxide donor. Carries an FDA black box warning.

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Evidence & regulatory context

Mechanism: ACTIVATOR of soluble guanylate cyclase (heterodimer; beta 1 or 2 subunit is the binding site). Nitric oxide donor. Carries an FDA black box warning.
Target: CHEMBL2111348 (soluble guanylate cyclase)
Injury models: Other
Reported indication: Not recorded
First approval: 1981
Development stage: Not recorded
ChEMBL record: CHEMBL2097081 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Sodium nitroprusside; Nitroprusside sodium; Nipride; Nipruss; Nitropress; NSC-755844
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02225561 ↗PHASE3terminated

SNPeCPR Pour la Prise en Charge Des Arrets Cardiaques Extrahospitaliers

Cardiopulmonary Arrest

Enrolment: 1 · Results not recorded

NCT03318094 ↗PHASE1active not recruiting

Vanderbilt University Medical Center: phentolamine and sodium nitroprusside vascular study in insulin resistance and obesity

Insulin Resistance · Healthy · Obesity

Enrolment: 36 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29902384 ↗2018Reported benefit

Abrupt Deflation after Sustained Inflation Causes Lung Injury.

RatOtherSprague-DawleyMalen = 6 per group for the main ventilation comparison, 4 per grou…Given in association with the deflation manoeuvre

Model: Ventilator-induced lung injury caused by abrupt deflation to zero positive end-expiratory pressure after sustained inflation (positive end-expiratory pressure raised from 3 to 11 cm H2O over 70 min), with low tidal volume ventilation at 6 ml/kg

Abrupt deflation reduced compliance (0.48 +/- 1.0 vs 0.82 +/- 0.2) and oxygen saturation (67 +/- 23.5% vs 91 +/- 4.4%) and increased wet to dry ratio (6.1 +/- 0.6 vs 4.6 +/- 0.4) with predominantly endothelial injury. Sodium nitroprusside prevented the rise in systemic blood pressure and left ventr…

Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.

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