Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage.
RatHaemorrhage/shockUnspecifiedWistarn = 4 to 8 animals per group in the reported histology and mark…Intravenous bolus administered over 10 minutes1 to 4 mg/kg dissolved in 250 microlitres salineAfter the haemorrhage phase was completed, described by the authors as a clinic…
Model: Rodent trauma and haemorrhagic shock model with varying degrees of tissue injury, plus purified mitochondrial DNA injection experiments
Hexadimethrine bromide significantly attenuated the rise in circulating nuclear DNA at 1 mg/kg with a non-significant trend towards reduced mitochondrial DNA, normalised phosphorylated NF-kappaB at 2 and 4 mg/kg, and improved lung histology, cell death and oxidative injury markers in a dose-depende…
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