Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction.
RatChemical/toxinSprague-DawleyMalen = 72 male Sprague-Dawley rats in total across all groupsIntragastric administrationCommenced after the operation or intoxication
Model: Acute cholestatic liver injury induced by thioacetamide at 200 mg/kg intraperitoneally dissolved in saline, and by bile duct ligation
Huang-Lian-Jie-Du-Decoction attenuated inflammatory cell infiltration in hepatocytes and collagenic exudation in the liver, reduced renal lesions, and restored disturbed metabolic features common to both cholestasis models including redox imbalance and gut flora disturbance, as well as the perturbe…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.