THERAPY DOSSIER · th-b9504bbf611a

Huang-Lian-Jie-Du-Decoction

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05613062 ↗PHASE1/PHASE2completed

Modified Huang-Lian-Jie-Du Decoction (MHLJDD) for Atopic Dermatitis in Children

Atopic Dermatitis

Enrolment: 20 · Results not recorded

NCT03469232 ↗PHASE1/PHASE2unknown

Huanglian-Jiedu Decoction in Intense-exuberant Stomach Fire Syndrome

Acute Pericoronitis · Recurrent Aphthous Stomatitis · Recurrent Herpes Simplex Labialis

Enrolment: 240 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29867467 ↗2018Reported benefit

Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction.

RatChemical/toxinSprague-DawleyMalen = 72 male Sprague-Dawley rats in total across all groupsIntragastric administrationCommenced after the operation or intoxication

Model: Acute cholestatic liver injury induced by thioacetamide at 200 mg/kg intraperitoneally dissolved in saline, and by bile duct ligation

Huang-Lian-Jie-Du-Decoction attenuated inflammatory cell infiltration in hepatocytes and collagenic exudation in the liver, reduced renal lesions, and restored disturbed metabolic features common to both cholestasis models including redox imbalance and gut flora disturbance, as well as the perturbe…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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