Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers affecting NF-kappaB, NOS2 and NRF2 expression.
MouseIschaemia-reperfusionOther / unspecifiedMaleDaily from after the last ischaemia and reperfusion cycle until euthanasia
Model: Pressure ulcer induced by two cycles of ischaemia and reperfusion using external application of two magnetic plates to the dorsal skin
Caffeic acid phenethyl ester brought forward the inflammatory response and oxidative damage at day 3 with reduction by day 7, increased myofibroblast density at day 7 and reduced it by day 12, and promoted collagen deposition, re-epithelialisation and wound closure of pressure ulcers by day 12.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.