Professor, Ege University Faculty of Dentistry (CAPE-containing adhesive study)
Matrix Metalloproteinase Inhibitors · Composite Resins
Enrolment: 10 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Matrix Metalloproteinase Inhibitors · Composite Resins
Enrolment: 10 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: hemi-transection spinal cord injury (thoracic)
CAPE enhanced locomotor recovery, reduced lesion size and suppressed IL-1beta, iNOS and COX-2 expression after spinal cord injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Pressure ulcer induced by two cycles of ischaemia and reperfusion using external application of two magnetic plates to the dorsal skin
Caffeic acid phenethyl ester brought forward the inflammatory response and oxidative damage at day 3 with reduction by day 7, increased myofibroblast density at day 7 and reduced it by day 12, and promoted collagen deposition, re-epithelialisation and wound closure of pressure ulcers by day 12.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute dichlorvos (organophosphate) intoxication causing hepatotoxicity and pancreatic injury
CAPE and intralipid raised total antioxidant status and reduced apoptotic and mitotic cell counts in liver, with pancreatic necrosis replaced by only mild congestion and oedema after treatment.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute spinal cord injury by aneurysm clip compression after lower thoracic laminectomy
CAPE suppressed serum TNF-alpha and IL-1beta after acute spinal cord injury and reduced histopathological haemorrhage and necrosis in the early phase.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Single 30 Gy beta-ray irradiation to the upper abdomen producing acute hepatic injury
Pretreatment significantly decreased serum alanine and aspartate aminotransferase and increased superoxide dismutase and glutathione activity, with histology confirming protection against radiation hepatotoxicity. Hepatocyte apoptosis was inhibited and NF-kappaB p65 nuclear transport, TNF-alpha, ni…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Ischaemia and reperfusion urogenital injury caused by 60 minutes of pneumoperitoneum at 15 mmHg, with tissues taken one hour before the desufflation period as described by the authors
Pneumoperitoneum raised total oxidant status and lowered total antioxidant status in kidney and testis and reduced the Johnsen score, and caffeic acid phenethyl ester prevented these changes, with no differences in prostate or in kidney and testis histology.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.