High-dose Factor XIII administration induces effective hemostasis for trauma-associated coagulopathy (TAC) both in vitro and in rat hemorrhagic shock in vivo models.
RatHaemorrhage/shockUncontrolledSprague-DawleyMale300 IU/kg in vivo; 3.6 to 32.4 IU/mL in vitro
Model: Liver trauma model with haemorrhagic shock and trauma-associated coagulopathy
High-dose Factor XIII improved clot strength and resistance to hyperfibrinolysis in vitro and increased platelet function dose-dependently. In the rat liver trauma model, Factor XIII reduced total bleeding (108.9 plus or minus 11.4 versus 32.6 plus or minus 5.5 mL/kg, p less than 0.001) and prolong…
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