Early Factor XIII Replacement in Postpartum Hemorrhage: Multi-center, Randomized, Controlled, Investigator-initiated Trial
Postpartum Hemorrhage · Coagulation Disorder · Hemorrhage
Enrolment: 988 · Results not recorded
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Biologic · No ChEMBL mechanism record returned for catridecacog.
6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postpartum Hemorrhage · Coagulation Disorder · Hemorrhage
Enrolment: 988 · Results not recorded
Congenital Bleeding Disorder · Congenital FXIII Deficiency
Enrolment: 63 · Results not recorded
Congenital Bleeding Disorder · Congenital FXIII Deficiency
Enrolment: 6 · Results not recorded
Acquired Bleeding Disorder · Cardiac Surgery Requiring Cardiopulmonary Bypass
Enrolment: 43 · Results not recorded
Congenital Bleeding Disorder · Congenital FXIII Deficiency
Enrolment: 11 · Results not recorded
Congenital Bleeding Disorder · Congenital FXIII Deficiency
Enrolment: 8 · Results not recorded
Factor XIII Deficiency
Enrolment: 61 · Results not recorded
Factor XIII Deficiency
Enrolment: 15 · Results not recorded
Inflammation · Ulcerative Colitis
Enrolment: 20 · Results not recorded
Hemophilia · Factor XIII Deficiency
Enrolment: 72 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Liver trauma model with haemorrhagic shock and trauma-associated coagulopathy
High-dose Factor XIII improved clot strength and resistance to hyperfibrinolysis in vitro and increased platelet function dose-dependently. In the rat liver trauma model, Factor XIII reduced total bleeding (108.9 plus or minus 11.4 versus 32.6 plus or minus 5.5 mL/kg, p less than 0.001) and prolong…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.