Electrospun Heparin-Loaded Core-Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo.
RatOtherSprague-DawleyMaleLocal, implanted as surgical suture at the tendon repair siteAt the time of tendon repair surgery
Model: Acute Achilles tendon rupture repaired by suture
The high-heparin-concentration suture (PPH3.0) outperformed low-heparin and commercial sutures, recruiting fewer inflammatory cells, showing good histocompatibility and reducing immune and inflammatory responses at the repair zone. Vascular endothelial growth factor concentration increased by 37.5…
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