THERAPY DOSSIER · th-8b187c6bb3c6

Heparin-loaded core-shell nanofiber sutures fabricated by near-field electrospinning (PPH3.0 high heparin concentration)

Device · Heparin-loaded core-shell electrospun nanofibre sutures; biomaterial device.

Evidence & regulatory context

Mechanism: Heparin-loaded core-shell electrospun nanofibre sutures; biomaterial device.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29806211 ↗2018Reported benefit

Electrospun Heparin-Loaded Core-Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo.

RatOtherSprague-DawleyMaleLocal, implanted as surgical suture at the tendon repair siteAt the time of tendon repair surgery

Model: Acute Achilles tendon rupture repaired by suture

The high-heparin-concentration suture (PPH3.0) outperformed low-heparin and commercial sutures, recruiting fewer inflammatory cells, showing good histocompatibility and reducing immune and inflammatory responses at the repair zone. Vascular endothelial growth factor concentration increased by 37.5…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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