A concomitant bone fracture delays cognitive recovery from traumatic brain injury.
MouseTBIControlled cortical impactCD1malen = 20 mice, 5 per group across four groupsSubcutaneous0.8 mg/kgFirst dose 2 h after injury
Model: Controlled cortical impact (left 4 mm craniotomy, 3 mm impactor tip, 6 m/s velocity, 1.0 mm cortical deformation) with or without a concomitant open right tibial diaphyseal fracture repaired by intramedullary fixation; sham craniotomy controls
A concomitant tibial fracture worsened Garcia Neurologic Test scores on days 2 to 4, slowed Morris water maze learning (escape latency 50.7 versus 30.3 s on day 17) and impaired probe trial memory (8.6 versus 22.7 s in sham), with more glial fibrillary acidic protein positive astrocytes in penumbra…
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