The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury: An experimental rat model.
RatIschaemia-reperfusionLimb / skeletal muscleWistar-albinomalen = 16 male Wistar-albino rats in two groups of 8
Model: Hind limb skeletal muscle ischaemia-reperfusion produced by femoral artery clamping for 2 h followed by reperfusion
Montelukast-treated animals had significantly lower muscle malondialdehyde (p = 0.002) and significantly higher superoxide dismutase (p = 0.001) than ischaemia-reperfusion controls, with significantly less oedema, polymorphonuclear infiltration and erythrocyte extravasation on histopathology.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.