Coenzyme Q10 combined with trimetazidine in the prevention of contrast-induced nephropathy in patients with coronary heart disease complicated with renal dysfunction undergoing elective cardiac catheterization: a randomized control study and in vivo study.
RatChemical/toxinSprague-DawleyMalen = n = 8 per group (animal arm); parallel randomised clinical…Oral gavage10 mg/kg or 20 mg/kg of each drugThree days before contrast medium injection and again 4 h after
Model: Contrast medium-induced acute kidney injury: 72 h water deprivation, furosemide 10 mg/kg intramuscularly, then 20 min later iohexol (350 mg I/mL) 10 mL/kg intravenously via tail vein over 5 min
Coenzyme Q10 plus trimetazidine dose-dependently lowered blood urea nitrogen and creatinine, reduced lipid peroxidation, raised glutathione, superoxide dismutase and catalase, and reduced tubular necrosis scores relative to contrast medium alone.
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