Anti-oxidant Therapy and Postoperative Cardiac Events (ACE) Trial, Preoperative Intervention in Vascular Surgery
Myocardial Injury
Enrolment: 341 · Results not recorded
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Drug · Supplement
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Myocardial Injury
Enrolment: 341 · Results not recorded
Burn Injury
Enrolment: 50 · Results not recorded
Statin Therapy
Enrolment: 40 · Results not recorded
IVF
Enrolment: 200 · Results not recorded
Multiple Organ Failure
Enrolment: 0 · Results not recorded
Bipolar Affective Disorder · Depression
Enrolment: 0 · Results not recorded
Parkinson Disease
Enrolment: 11 · Results not recorded
Heart Failure, Diastolic
Enrolment: 216 · Results not recorded
Vestibular Function Disorder
Enrolment: 0 · Results not recorded
Huntington Disease
Enrolment: 6 · Results not recorded
CoQ10 Blood Levels
Enrolment: 24 · Results not recorded
Gingival Recession
Enrolment: 30 · Results not recorded
Hepatic Encephalopathy · Coenzyme Q10 · Intellectual Functioning Disability
Enrolment: 300 · Results not recorded
Bioavailability of Coenzyme Q10
Enrolment: 30 · Results not recorded
Coenzyme Q10 Pharmacokinetics
Enrolment: 15 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Contrast medium-induced acute kidney injury: 72 h water deprivation, furosemide 10 mg/kg intramuscularly, then 20 min later iohexol (350 mg I/mL) 10 mL/kg intravenously via tail vein over 5 min
Coenzyme Q10 plus trimetazidine dose-dependently lowered blood urea nitrogen and creatinine, reduced lipid peroxidation, raised glutathione, superoxide dismutase and catalase, and reduced tubular necrosis scores relative to contrast medium alone.
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
Model: Crush injury of the right facial nerve
Coenzyme Q10 produced greater improvement in stimulation threshold than saline and significantly better vascular congestion, macrovacuolisation and myelin thickness, although neither group returned to pre-crush amplitude.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Contusive traumatic brain injury
Ubiquinol given either before or after injury acutely reduced brain mitochondrial damage, apoptosis and the serum injury biomarkers glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1. In vivo proton magnetic resonance spectroscopy showed no attenuation of injury-induced neurometa…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.