Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.

PMID 29775479 ↗2018Reported benefit

Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.

RatSpinal cord injuryComplete transectionLewisMalen = n = 6 per experimental group (24 rats total); 3 rats per gr…Inhalation in a Plexiglas chamberTen 5 min episodes of 11% inspired oxygen alternating with…Treatment commenced 4 weeks after cervical spinal cord injury

Model: Unilateral (left) transection of the dorsolateral funiculus at C2 with a modified 25-gauge bevel-tipped needle after C2-C3 laminectomy and durotomy under isoflurane

Acute intermittent hypoxia raised neuronal HIF-1alpha after 1 and 7 days; vascular endothelial growth factor, brain-derived neurotrophic factor, TrkB and phosphorylated TrkB rose only after 7 days, at both cervical and lumbar levels.

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Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.

Evidence by therapy association

Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.