THERAPY DOSSIER · th-c1341a7dff2d

Acute intermittent hypoxia plus ladder rehabilitative training

Procedure · Acute intermittent hypoxia plus ladder rehabilitative training; physiological/rehabilitation procedure.

Evidence & regulatory context

Mechanism: Acute intermittent hypoxia plus ladder rehabilitative training; physiological/rehabilitation procedure.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01272336 ↗Injury indicationPHASE1completed

Intermittent Hypoxia Promotes Restoration of Hand Function Following Spinal Cord Injury

Spinal Cord Injury

Enrolment: 53 · Results not recorded

NCT03780829 ↗Injury indicationEARLY_PHASE1terminated

Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair

Spinal Cord Injury

Enrolment: 50 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29775479 ↗2018Reported benefit

Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.

RatSpinal cord injuryComplete transectionLewisMalen = n = 6 per experimental group (24 rats total); 3 rats per gr…Inhalation in a Plexiglas chamberTen 5 min episodes of 11% inspired oxygen alternating with…Treatment commenced 4 weeks after cervical spinal cord injury

Model: Unilateral (left) transection of the dorsolateral funiculus at C2 with a modified 25-gauge bevel-tipped needle after C2-C3 laminectomy and durotomy under isoflurane

Acute intermittent hypoxia raised neuronal HIF-1alpha after 1 and 7 days; vascular endothelial growth factor, brain-derived neurotrophic factor, TrkB and phosphorylated TrkB rose only after 7 days, at both cervical and lumbar levels.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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