Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats.
RatRadiationProphylactic dosing before irradiation and therapeutic dosing after irradiation…
Model: Acute radiation proctitis induced by irradiation of the rectum
Sildenafil significantly reduced histopathological injury scores and inflammatory marker immunoreactivity relative to untreated radiation proctitis, and the prophylactic regimen outperformed the therapeutic regimen histopathologically; the high-dose group behaved similarly to the prophylaxis group.
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