Celastrol attenuates incision-induced inflammation and pain associated with inhibition of the NF-kappaB signalling pathway via SARM.
RatWoundSprague-DawleymaleIntraplantar injection5 microgram/paw, 10 microgram/paw and 20 microgram/pawBefore plantar surgical incision
Model: Plantar surgical incision of the hind paw
Celastrol partially reversed incision-induced pain behaviour, reduced proinflammatory cytokine mRNA and p-p65 and p65 levels, and increased SARM and IkBalpha expression. Knockdown of SARM by shRNA partially abolished these protective effects.
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