The Preventive Role of Pioglitazone in Glycerol-Induced Acute Kidney Injury in Rats during Two Different Treatment Periods.
RatChemical/toxinAlbino Wistarmalen = n=6 per group, 24 rats in totalOral gavage via intubation needle10 mg/kg (1 mg/mL suspension in 0.5% w/v carboxymethyl cell…Pretreatment, beginning 3 days (group C) or 6 days (group D) before glycerol in…
Model: Rhabdomyolysis-induced acute kidney injury by intramuscular injection of 50% glycerol 10 mL/kg divided between both hind limbs, with water deprivation for 24 h beforehand; animals killed 24 h after glycerol
Glycerol raised serum creatinine to 3.447 mg/dL and urea to 146.3 mg/dL and depleted glutathione to 1.404 mg/g. Pioglitazone reduced creatinine to 2.39 mg/dL (3 days) and 2.072 mg/dL (6 days) and raised glutathione, with no significant difference between the 3-day and 6-day regimens.
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.