Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation.
MouseRadiationBALB/c (embryonic stem cells derived from BALB/cJ blastocysts)male and femaleIntravenous for intestinal lineage cells; route of the oligodeoxynucleotide not statedAntisense oligodeoxynucleotide dose not stated; intestinal…Oligodeoxynucleotide from 3 days after irradiation; cell transplantation at 2 a…
Model: Whole-body gamma irradiation with a caesium-137 source (0.662 MeV) at 1.05 Gy/min, 5 Gy or 7-10 Gy, producing gastrointestinal acute radiation syndrome; secondary sepsis induced by oral Enterococcus faecalis after antibiotic decontamination and lansoprazole 0.5 mg/mouse
All 7-9 Gy irradiated mice given scrambled oligodeoxynucleotide died, whereas all 7 and 8 Gy and 70% of 9 Gy mice given CCL1 antisense oligodeoxynucleotide survived. At 10 Gy, all mice given both the oligodeoxynucleotide and intestinal lineage cells survived while mice given either alone died withi…
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