Evidence & regulatory context
- Mechanism
- Composite preclinical intervention: CCL1 (I-309/TCA-3) antisense oligodeoxynucleotide knockdown combined with transplantation of intestinal-lineage cells differentiated from murine embryonic stem cells. No ChEMBL entity (antisense oligonucleotide sequence plus a cell therapy) and no ClinicalTrials.gov record; entirely preclinical.
- Target
- Not recorded
- Injury models
- Radiation · Burn
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseRadiationBALB/c (embryonic stem cells derived from BALB/cJ blastocysts)male and femaleIntravenous for intestinal lineage cells; route of the oligodeoxynucleotide not statedAntisense oligodeoxynucleotide dose not stated; intestinal…Oligodeoxynucleotide from 3 days after irradiation; cell transplantation at 2 a…
Model: Whole-body gamma irradiation with a caesium-137 source (0.662 MeV) at 1.05 Gy/min, 5 Gy or 7-10 Gy, producing gastrointestinal acute radiation syndrome; secondary sepsis induced by oral Enterococcus faecalis after antibiotic decontamination and lansoprazole 0.5 mg/mouse
All 7-9 Gy irradiated mice given scrambled oligodeoxynucleotide died, whereas all 7 and 8 Gy and 70% of 9 Gy mice given CCL1 antisense oligodeoxynucleotide survived. At 10 Gy, all mice given both the oligodeoxynucleotide and intestinal lineage cells survived while mice given either alone died withi…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
MouseBurnUnspecifiedNOD scid gamma (NSG) and other burned mouse strainsGiven both before infection and therapeutically after methicillin-resistant Sta…
Model: Thermal burn of 5%, 15% or 25% total body surface area followed by methicillin-resistant Staphylococcus aureus infection in the sub-acute phase
All mice with 25% total body surface area burn treated with CCL1 antisense oligodeoxynucleotide survived methicillin-resistant Staphylococcus aureus infection whereas all untreated mice died within 4 days, with recovery of M1 macrophages and control of sepsis when the oligodeoxynucleotide was given…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
