Effects of long-term rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice.
MouseTBICryogenicICRmaleIntraperitoneal0.5 mg/kg or 1.5 mg/kgBeginning 1 h after cryogenic traumatic brain injury
Model: Cryogenic traumatic brain injury (cTBI)
At 3 days, rapamycin 1.5 mg/kg worsened motor deficits and increased infarct size while attenuating astrocyte reactivation, whereas 0.5 mg/kg did not worsen damage. At 7 and 14 days, 0.5 mg/kg improved motor performance and reduced glial scar area, thickness and chondroitin sulfate proteoglycan exp…
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