Dietary alpha-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis.
MouseChemical/toxinICRmalen = n=8 per group, four groups (32 in total)Intragastric100 and 200 mg/kg body weightPretreatment beginning 5 days before acetaminophen, with the last dose 1 h befo…
Model: Acute liver injury induced by a single dose of acetaminophen 250 mg/kg dissolved in warm water, injected on the sixth day 1 h after the last alpha-mangostin dose; mice killed 24 h after acetaminophen
alpha-Mangostin significantly reduced acetaminophen-induced rises in serum ALT and AST, inhibited hepatic glutathione depletion and malondialdehyde production dose-dependently, and lowered TNF-alpha and IL-1beta. It reduced TUNEL-positive apoptosis, Bax and cleaved caspase 3 and the LC3 II/I ratio…
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