Efficacy and Tolerability of Garcinia Mangostana Extracts in the Management of Weight Loss in Severe Obese Patients
Severe Obesity
Enrolment: 40 · Results not recorded
Loading the evidence…
Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Severe Obesity
Enrolment: 40 · Results not recorded
Exertion; Excess · Oxidative Stress
Enrolment: 30 · Results not recorded
Recurrent Aphthous Stomatitis
Enrolment: 48 · Results not recorded
Atrial Fibrillation
Enrolment: 143 · Results not recorded
Healthy Volunteers
Enrolment: 10 · Results not recorded
Generalized Chronic Periodontitis
Enrolment: 50 · Results not recorded
Osteoarthritis, Knee
Enrolment: 95 · Results not recorded
Type 2 Diabetes · Dyslipidemia · Insulin Resistance
Enrolment: 58 · Results not recorded
Dietary Modification
Enrolment: 10 · Results not recorded
Apoptosis
Enrolment: 2 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute liver injury induced by a single dose of acetaminophen 250 mg/kg dissolved in warm water, injected on the sixth day 1 h after the last alpha-mangostin dose; mice killed 24 h after acetaminophen
alpha-Mangostin significantly reduced acetaminophen-induced rises in serum ALT and AST, inhibited hepatic glutathione depletion and malondialdehyde production dose-dependently, and lowered TNF-alpha and IL-1beta. It reduced TUNEL-positive apoptosis, Bax and cleaved caspase 3 and the LC3 II/I ratio…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.