The Therapeutic Effects after Transplantation of Whole-Layer Olfactory Mucosa in Rats with Optic Nerve Injury.
RatCrushOther / unspecifiedLewis (inbred, syngeneic donor and recipient)MaleLocal transplantation into the optic nerve lesion sitePieces of whole-layer olfactory mucosa transplanted into th…Acutely, at the time of optic nerve crush
Model: Crush injury of the right optic nerve
Olfactory mucosa transplantation increased retinal ganglion cell survival and axonal growth and raised GAP-43 while lowering retinal GFAP compared with phosphate buffered saline. The full text notes the protective effect on injured neurons is present within two weeks but weakens or disappears by fo…
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